Real-world evidence of safety and effectiveness of Barrett’s endoscopic therapy
[ad_1]
Dr Prateek Sharma
Dr Sharma has been at the forefront and a pioneer in improving the diagnosis and management of GI diseases and cancer, specifically GERD, Barrett’s esophagus, advanced imagi LESS
… MORE
Background: Barrett’s esophagus (BE) is a condition where the lining of the food pipe changes, often due to long-term acid reflux. Sometimes, this condition can lead to more serious problems like dysplasia (abnormal cell growth) or esophageal adenocarcinoma (EAC), a type of cancer.
Summary: This study aimed to understand the safety and effectiveness of Barrett’s endoscopic therapy (BET) in patients with neoplastic Barrett’s esophagus (BE) using real-world data. Researchers used a database of electronic health records (TriNetX) to select patients with BE showing signs of dysplasia or esophageal adenocarcinoma between 2016 and 2020.
The primary focus was on comparing the 3-year survival rates among patients with high-grade dysplasia (HGD) or EAC who underwent BET versus those who didn’t, and also against a comparison group of patients with gastroesophageal reflux disease (GERD) but no BE/EAC. They also looked at adverse events like esophageal perforation, bleeding, chest pain, and esophageal stricture after BET.
They found that among patients with HGD or EAC, those who underwent BET had significantly lower 3-year mortality rates compared to those who did not have the therapy. However, there was no significant difference in 3-year mortality rates between patients with GERD without BE/EAC and those with HGD who had BET. Interestingly, they found similar survival rates between patients who had BET and those who underwent esophagectomy (surgery to remove part of the esophagus) for both HGD and EAC.
The study also noted that the most common adverse event after BET was esophageal stricture, occurring in about 6.5% of treated patients. Overall, the findings suggest that BET is safe and effective for patients with neoplastic Barrett’s esophagus, reducing mortality rates but posing a risk of esophageal stricture in a small percentage of treated individuals.
Read full research: Real-world evidence of safety and effectiveness of Barrett’s endoscopic therapy
Disclaimer
Views expressed above are the author’s own.
END OF ARTICLE
[ad_2]
Source link
